THIS! Borderlands and GTA A town under constant siege by various crazy psychos and an armory of weapons to choose from. Crimson lance police, civillians all armed with those pathetic pistols you can find in borderlands explosions everywhere!
The depth & length of Dwarf Fortress, The Combat & Control of God of War, And the interactivity of Neverwinter Nights.
I have big plans.
Show them your butt, and when you do, slap it so it creates a sound akin to a chorus of screaming spider monkeys flogging a chime with cacti. Only then can you find your destiny at the tip of the shaft.
Starcraft x FinalFantasy: Tactics Street fighter x Tekken x Touhou x King of fighters x Soul caliber x Guilty Gear x Marvel VS. Capcom x BlazBlue x Battleraper
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Halo + CoD
I actually came here to say Final Fantasy Tactics / Starcraft. I'm glad somebody else enjoys those games as much as me.
Mortal Kombat and Halo (Rather just a large scale action game with mad combo maneuvers.) Starfox and R-Type Command Conkers Bad Fur Day should also be paired with something, but I can't think of anything that would make it better.